منابع مشابه
Polyphosphate nucleosides of purine analogues.
To test the hypothesis that carcinostatic purine and pyrimidine analogues exert their effects at the nucleotide level, we have undertaken the preparation and study of nucleotides, including coenzymes, which contain analogues in place of the natural bases. An earlier communication from this laboratory (1) described the enzymatic synthesis and isolation of 5’-nucleotides of a number of purine ana...
متن کاملPurines, Purine Nucleosides, and Analogues
Of 142 purines, purine nucleosides, and analogues tested for inhibition of growth of Escherichia coli B Hill, 45 were active. Of these, 27 were evaluated for inhibition of other E. coli lines, including those resistant to 6-thioguanine, 2-fluoroadenosine, 2,6-diaminopurine, or 6-mercaptopurine. Most toxic to the parent lines were 2-fluoroadenosine, 2-fluoroadenine, 2-fluoro-5'-deoxyadenosine, a...
متن کاملpurine) nucleosides into hepatic RNA
The absorption and metabolism of dietary nucleic acids have received less attention than those of other organic nutrients, largely because of methodological difficulties. We supplemented the rations of poultry and mice with the edible alga Spirulina platensis, which had been uniformly labeled with '3C by hydroponic culture in 13CO2. The rations were ingested by a hen for 4 wk and by four mice f...
متن کاملPurine nucleosides: endogenous neuroprotectants in hypoxic brain
Even a short blockade of oxygen flow in brain may lead to the inhibition of oxidative phosphorylation and depletion of cellular ATP, which results in profound deficiencies in cellular function. Following ischemia, dying, injured, and hypoxic cells release soluble purine-nucleotide and -nucleoside pools. Growing evidence suggests that purine nucleosides might act as trophic factors in the CNS an...
متن کاملTransport of nucleosides in Bacillus subtilis: the effect of purine nucleosides on the cytidine-uptake.
The structural effects of chemical modifications upon the affinity of purine nucleosides to cytidine-transport system in Bacillus subtilis were investigated using a series of modified derivatives. The interaction involves protein molecule(s) which require the presence and proper orientation of the sugar residue and its hydroxylic functions. Moreover, a specific interaction with the heterocyclic...
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ژورنال
عنوان ژورنال: Nature
سال: 1943
ISSN: 0028-0836,1476-4687
DOI: 10.1038/151109a0